https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33427 Wed 31 Oct 2018 15:13:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43743 Wed 28 Sep 2022 10:51:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54154 Wed 28 Feb 2024 15:02:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46637 Wed 28 Feb 2024 14:49:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42519 Wed 24 Aug 2022 11:17:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46450 Wed 23 Nov 2022 14:17:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33577 in vitro and that C3a receptor signalling stimulates neurogenesis in unchallenged adult mice. To determine the role of C3a-C3a receptor signalling in ischaemia-induced neural plasticity, we subjected C3a receptor-deficient mice, GFAP-C3a transgenic mice expressing biologically active C3a in the central nervous system, and their respective wild-type controls to photothrombotic stroke. We found that C3a overexpression increased, whereas C3a receptor deficiency decreased post-stroke expression of GAP43 (P < 0.01), a marker of axonal sprouting and plasticity, in the peri-infarct cortex. To verify the translational potential of these findings, we used a pharmacological approach. Daily intranasal treatment of wild-type mice with C3a beginning 7 days after stroke induction robustly increased synaptic density (P < 0.01) and expression of GAP43 in peri-infarct cortex (P < 0.05). Importantly, the C3a treatment led to faster and more complete recovery of forepaw motor function (P < 0.05). We conclude that C3a-C3a receptor signalling stimulates post-ischaemic neural plasticity and intranasal treatment with C3a receptor agonists is an attractive approach to improve functional recovery after ischaemic brain injury.]]> Wed 17 Nov 2021 16:30:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49900 0.05). Following both protocols, the masters cyclists exhibited a higher final blood lactate value (CON: d ± 90%CI = -0.97 ± 0.80, moderate; HIT: d = -0.70 ± 0.81, moderate) and a lower percent change (CON: d = -0.84 ± 0.87, moderate; HIT: d = -0.70 ± 0.85, moderate) during recovery. To mitigate any influence of masters athletes’ diminished blood lactate clearance, it is recommended that extra recovery time or active recovery strategies be used in masters athletes following exercise.]]> Wed 14 Jun 2023 12:00:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50743 Wed 13 Sep 2023 15:42:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44629 Wed 13 Mar 2024 14:03:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40238 Wed 13 Mar 2024 08:50:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50103 Wed 12 Jul 2023 14:00:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21956 Wed 11 Apr 2018 17:14:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30395 Rhinella marina) in Australia, which has caused severe population declines in monitor lizards, triggering trophic cascades that facilitated dramatic and sometimes unexpected increases in several prey of the predators, including smaller lizards, snakes, turtles, crocodiles, and birds. Persistence of isolated populations of these predators with a decades-long sympatry with toads suggests the possibility of recovery, but alternative explanations are possible. Confirming predator recovery requires longer-term study of populations with both baseline and immediate post-invasion densities. Previously, we quantified short-term impacts of invasive cane toads on animal communities over seven years at two sites in tropical Australia. Herein, we test the hypothesis that predators have begun to recover by repeating the study 12 yr after the initial toad invasion. The three predatory lizards that experienced 71–97% declines in the short-term study showed no sign of recovery, and indeed a worse fate: two of the three species were no longer detectable in 630 km of river surveys, suggesting local extirpation. Two mesopredators that had increased markedly in the short term due to these predator losses showed diverse responses in the medium term; a small lizard species increased by ~500%, while populations of a snake species showed little change. Our results indicate a system still in ecological turmoil, having not yet reached a “new equilibrium” more than a decade after the initial invasion; predator losses due to this toxic invasive species, and thus downstream effects, were not transient. Given that cane toads have proven too prolific to eradicate or control, we suggest that recovery of impacted predators must occur unassisted by evolutionary means: dispersal into extinction sites from surviving populations with alleles for toxin resistance or toad avoidance. Evolution and subsequent dispersal may be the only solution for a number of species or communities affected by invasive species for which control is either prohibitively expensive, or not possible.]]> Wed 11 Apr 2018 17:13:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16735 Wed 11 Apr 2018 15:21:39 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30041 Wed 11 Apr 2018 15:12:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30202 Wed 11 Apr 2018 14:45:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27456 Wed 11 Apr 2018 14:31:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22342 Wed 11 Apr 2018 14:27:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21965 Wed 11 Apr 2018 14:26:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25679 Wed 11 Apr 2018 12:32:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25719 Wed 11 Apr 2018 11:08:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10769 Wed 11 Apr 2018 10:39:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30832 Wed 11 Apr 2018 09:33:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34073 Wed 09 Mar 2022 16:04:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29905 Wed 09 Mar 2022 16:00:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34066 Wed 06 Feb 2019 09:50:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50540 Wed 02 Aug 2023 14:40:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33326 Tue 16 Oct 2018 11:26:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48333 Tue 14 Mar 2023 17:01:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48319 Tue 14 Mar 2023 15:37:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52359 Tue 10 Oct 2023 09:15:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54146 Tue 06 Feb 2024 12:04:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54607 Tue 05 Mar 2024 09:05:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39917 Thu 30 Jun 2022 11:48:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33721 Thu 28 Oct 2021 12:36:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:635 Thu 25 Jul 2013 09:10:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43274 Thu 15 Sep 2022 12:10:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31009 Thu 13 Jan 2022 10:32:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31275 Thu 13 Jan 2022 10:30:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49312 Thu 11 May 2023 14:39:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8130 Sat 24 Mar 2018 08:40:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7856 Sat 24 Mar 2018 08:36:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2794 Sat 24 Mar 2018 08:27:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10819 Sat 24 Mar 2018 08:13:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11969 Sat 24 Mar 2018 08:09:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21753 Sat 24 Mar 2018 08:03:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20373 Sat 24 Mar 2018 07:58:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26100 Sat 24 Mar 2018 07:39:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28942 p < 0.05), as defined by a marked elevation in GFAP expression, within all 13 sites assessed within the ipsilateral (lesioned) hemisphere. We further observed significant increases in GFAP expression (p < 0.05) in 9 of the 13 contralesional sites examined. This work underscores that both the ipsilateral and contralesional hemispheres, at sites distal to the infarct, are very active many weeks after the initial occlusion, a finding that potentially has significant implications for understanding and improving the regeneration of the damaged brain.]]> Sat 24 Mar 2018 07:31:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26463 1). Results: Overall, 152 patients (82 left hemisphere) were included. Median diffusion lesion volume was 37.0 ml, and median baseline National Institutes of Health Stroke Score was 13. In the left hemisphere, the strongest determinants of nonfavorable outcome were infarction of the uncinate fasciculus, followed by precuneus, angular gyrus and total diffusion lesion volume. In the right hemisphere, the strongest determinants of nonfavorable outcome were infarction of the parietal lobe followed by the putamen. Conclusions: Assessment of infarct location using CART demonstrates regional characteristics associated with poor outcome. Prognostically important locations include limbic, default-mode and language areas in the left hemisphere, and visuospatial and motor regions in the right hemisphere.]]> Sat 24 Mar 2018 07:27:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23405 Sat 24 Mar 2018 07:13:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30785 60); ii) the time constant of the 30-min heart rate recovery curve (HRRτ); iii) the time course of the root mean square for successive 30-sec R–R interval (RMSSD₃₀); and iv) time and frequency domain analyses of subsequent 5-min R–R interval segments. Results: No significant between-group differences were observed for HRR₆₀ (P = 0.096) or HRRτ (P = 0.617). However, a significant interaction effect was found for RMSSD₃₀ (P = 0.021), with the master cyclists showing higher RMSSD₃₀ values following HIT. Similar results were observed in the time and frequency domain analyses with significant interaction effects found for the natural logarithm of the RMSSD (P = 0.008), normalised low-frequency power (P = 0.016) and natural logarithm of high-frequency power (P = 0.012). Conclusion: Following high-intensity interval training, master cyclists demonstrated greater post-exercise parasympathetic reactivation compared to young cyclists, indicating that physical training at older ages has significant effects on autonomic function.]]> Mon 23 Sep 2019 12:34:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31100 Mon 23 Sep 2019 10:15:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47585 Mon 23 Jan 2023 14:28:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49585 Mon 22 May 2023 12:22:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50986 Mon 14 Aug 2023 15:59:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52636 n = 1116), using visual analog scales (VAS) for recovery, hope, and other demographic variables. Findings show that many women rated themselves as completely recovered (14% of the eligible sample and 22% of the women who had left their partner > 10 years previously). However, most women experienced recovery as an ongoing process of healing (81%) and some women made little recovery progress (5%). Nevertheless, 77% of women who had separated >10 years ago rated their recovery as significant (scores of >70/100). Surprisingly, hope and recovery scores were only moderately correlated. This requires further investigation to determine what impacts on hope in long-term recovery, and how subjective and objective measures of hope and recovery vary in the context of IPV. The VAS was an efficient unidimensional measure for an online survey and is proposed for use in clinical and service contexts requiring subjective measures.]]> Mon 13 Nov 2023 08:47:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30995 Mon 12 Oct 2020 10:59:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55059 Mon 08 Apr 2024 12:32:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22551 Mon 02 Jul 2018 13:37:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36532 Mon 01 Jun 2020 12:02:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23891 Fri 18 Sep 2020 17:37:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47354 Fri 13 Jan 2023 13:20:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41794 Fri 12 Aug 2022 12:17:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46106 2AlC MAX phase thin films prepared by radio-frequency magnetron sputtering were irradiated at room temperature by 100 keV helium ions to a fluence of 1 × 10¹⁷ ions cm⁻². The effects of thermal annealing on the structural and mechanical properties of the helium-irradiated Cr₂AlC films as well as the helium release were investigated by grazing-incidence X-ray diffraction (GIXRD), Raman spectroscopy, and scanning electron microscope (SEM) in combination with nano-indentation and elastic recoil detection (ERD) analysis. The irradiation-induced structural damage in the Cr₂AlC is significantly recovered by thermal annealing at temperatures around 600℃, attributed to high defect diffusivity. After annealing to 750℃, the hardness of irradiated films recovered almost completely, which is ascribes to both defect recombination and reformation of damaged chemical bonds. Substantial helium release occurring at this annealing temperature is closely related to the damage recovery due to helium irradiation.]]> Fri 11 Nov 2022 12:05:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49196 Fri 05 May 2023 15:51:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45733 Fri 04 Nov 2022 09:58:56 AEDT ]]>